Ultrahigh dose-rate FLASH Radiotherapy: the Institut Curie experience
Annalisa Patriarca, Institut Curie, Hôpital, PSL Université Paris
Recent in vivo investigations have shown that short pulses of electrons at very high dose rates (FLASH) are less harmful to healthy tissues but just as efficient as conventional dose-rate radiation to inhibit tumour growth. In this talk, first we will describe the experiments that led to the definition of the FLASH effect performed at Institut Curie. We will also introduce a series of technological developments we have realized to investigate the biology of FLASH irradiation using a commercially available clinical proton therapy system. In view of the potential clinical value of FLASH, an overview of the international research around the topic will be reported.